ICAM1 Mouse Monoclonal Antibody [Clone ID: HM.2]

CAT#: AM26247BT-N

ICAM1 mouse monoclonal antibody, clone HM.2, Biotin


USD 270.00

2 Weeks*

Size
    • 50 ug

Product Images

Specifications

Product Data
Clone Name HM.2
Applications ELISA, IF, IHC, IP
Recommended Dilution Immunohistochemistry on frozen and paraffin section: The typical starting working dilution is 1:50.
Flow cytometry.
Immunoassay.
Immunoflourescence.
Immunoprecipitation.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Specificity The monclonal antibody HM.2 reacts with the 90 kD glycoprotein Intracellular Adhesion Molecule-1 (ICAM-1).
Formulation PBS
Label: Biotin
State: Liquid 0.2 µm filtered Ig fraction
Stabilizer: 0.1% bovine serum albumin
Preservative: 0.02% sodium azide
Concentration lot specific
Purification Protein G
Conjugation Biotin
Storage

Store at 2 - 8 °C.

Stability Shelf life: one year from despatch.

Gene Name intercellular adhesion molecule 1
Background

The adhesion molecule ICAM-1 belongs to the immunoglobulin superfamily, C2 subset; it is a ligand for the Integrins LFA-1 and MAC-1 and for CD43.
ICAM-1 is a essential component in many immune-related processes. ICAM-1 links with receptors of the integrin family, thereby mediating cell-cell interactions and allowing for signal transduction. ICAM-1 interacts specifically with its receptors to induce a reversible adhesion interaction. For processes like T cell activation and leucocyte recruitment, normal immune function relies on ICAM-1. Therefore, it is understandable that alterations in ICAM-1 structure or expression are associated with immune disorders. It is important to properly understand the various functions and regulatory mechanisms of ICAM-1, the resulting disease-related failures, and the various treatments.
ICAM-1 is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFalpha) and is expressed by the vascular endothelium, macrophages and lymphocytes.

Synonyms ICAM-1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.