ICAM1 Mouse Monoclonal Antibody [Clone ID: HM.2]

CAT#: AM26247PU-N

ICAM1 mouse monoclonal antibody, clone HM.2, Purified

Specifications

Product Data

• Clone Name: HM.2
• Applications: ELISA, IF, IHC, IP
• Recommended Dilution: Immunohistochemistry on frozen and paraffin section: The typical starting working dilution is 1:50.
  Flow cytometry.
  Immunoassay.
  Immunoflourescence.
  Immunoprecipitation.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Specificity: The monclonal antibody HM.2 reacts with the 90 kD glycoprotein Intracellular Adhesion Molecule-1 (ICAM-1).
• Formulation: PBS
  State: Purified
  State: Liquid 0.2 µm filtered Ig fraction
  Stabilizer: 0.1% bovine serum albumin
  Preservative: 0.02% sodium azide
• Concentration: lot specific
• Purification: Protein G
• Storage:

  Store at 2 - 8 °C.
  

• Stability: Shelf life: one year from despatch.

• Gene Name: intercellular adhesion molecule 1
• Database Link:
  Entrez Gene 3383 Human
• Background:

  The adhesion molecule ICAM-1 belongs to the immunoglobulin superfamily, C2 subset; it is a ligand for the Integrins LFA-1 and MAC-1 and for CD43.
  ICAM-1 is a essential component in many immune-related processes. ICAM-1 links with receptors of the integrin family, thereby mediating cell-cell interactions and allowing for signal transduction. ICAM-1 interacts specifically with its receptors to induce a reversible adhesion interaction. For processes like T cell activation and leucocyte recruitment, normal immune function relies on ICAM-1. Therefore, it is understandable that alterations in ICAM-1 structure or expression are associated with immune disorders. It is important to properly understand the various functions and regulatory mechanisms of ICAM-1, the resulting disease-related failures, and the various treatments.
  ICAM-1 is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFalpha) and is expressed by the vascular endothelium, macrophages and lymphocytes.

• Synonyms: ICAM-1