IL1 Receptor II (IL1R2) Mouse Monoclonal Antibody [Clone ID: 8.5]

CAT#: AM26271FC-N

IL1 Receptor II (IL1R2) mouse monoclonal antibody, clone 8.5, FITC

Specifications

Product Data

• Clone Name: 8.5
• Applications: ELISA, WB
• Recommended Dilution: Flow cytometry: The typical starting working dilution is 1:50.
  Immunoassay.
  Western blot: The typical starting working dilution is 1:50.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Specificity:
  The antibody reacts specificly with IL-1RII.
• Formulation: PBS
  Label: FITC
  State: Liquid 0.2 µm filtered Ig fraction
  Stabilizer: 1% bovine serum albumin
  Preservative: containing 0.02% sodium azide
• Concentration: 0.1 mg/ml
• Purification: Protein G
• Conjugation: FITC
• Gene Name: interleukin 1 receptor type 2
• Database Link:
  Entrez Gene 7850 Human
• Background: The IL-1 system includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1RI and IL-1RII) and the IL-1 receptor accessory protein. The IL-1RII is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signaling molecule which functions by capturing IL-1 and preventing it from interacting with the signalling IL-1RI. The decoy IL-1RII can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by coreceptor competition. Further a soluble form of IL-1RII exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes, polymorphonuclear cells, B cells and fibroblasts.
• Synonyms: Interleukin-1 receptor type II, IL-1R-2, IL-1R-beta, CDw121b, IL1RB