Timd4 Hamster Monoclonal Antibody [Clone ID: Kat5-18]

CAT#: AM26307PU-N

Timd4 hamster monoclonal antibody, clone Kat5-18, Purified

Specifications

Product Data

• Clone Name: Kat5-18
• Applications: ELISA, FN, IF
• Recommended Dilution: Flow cytometry: The typical starting working dilution is 1:50.
  Functional assays: Blocks the engulfment of apoptotic cells by thymic macrophages.
  Immunoassays.
  Immunoflourescence.
  Does not work in Immunohoistochemistry on frozen and paraffin sections or Western blot.
• Reactivities: Mouse
• Host: Hamster
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Mouse peritoneal cells
• Specificity: The monoclonal antibody Kat5-18 recognizes T-cell immunoglobulin and mucin domain containing molecule (TIMD-4, also called TIM-4).
• Formulation: PBS
  State: Purified
  State: Liquid purified 0.2 µm filtered purified Ig fraction
  Stabilizer: 0.1% bovine serum albumin
• Concentration: 0.1 mg/ml
• Database Link:
  Entrez Gene 276891 Mouse
• Background: TIMD-4 is a type I transmembrane protein belonging to the immunoglobulin superfamily, containing one Ig-like V-type (immunoglobulin-like) domain. TIMD-4 is expressed in Mac1+ cells in spleen, lymph nodes and fetal liver. TIMD-4 binds apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. TIMD-4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIMD-4 is involved in regulating T-cell proliferation and lymphotoxin signaling. TIMD-4 and TIMD-1 are phosphatidylserine receptors for the engulfment of apoptotic cells, and are also involved in intracellular signaling in which exosomes are involved.
• Synonyms: TIMD-4, TIM4, TIM-4, T-cell membrane protein 4