Jam3 Rat Monoclonal Antibody [Clone ID: JAM-C]

CAT#: AM26320PU-N

Jam3 rat monoclonal antibody, clone JAM-C, Purified


USD 405.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name JAM-C
Applications ELISA, FN, IHC, IP
Recommended Dilution Immunohistochemistry on frozen sections: The typical starting working dilution is 1:50.
Flow cytometry: The typical starting working dilution is 1:50.
Functional assays (inhibition of biological activity).
Immunoassays (detector).
Immunoprecipitation.
The antibody cannot be used for Western blot and immunohistology on paraffin sections.
Reactivities Human, Mouse
Host Rat
Isotype IgG2a
Clonality Monoclonal
Specificity The monoclonal antibody CRAM-18 F26 recognizes junctional adhesion molecule-C (JAM-C) also known as JAM-2, a 45 kD cell adhesion molecule (CAM).
In adult murine tissue JAM-C expression is reported to be restricted to high endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells in kidney. Monoclonal antibody CRAM-18 F26 also reacts with human JAM-C. In humans, JAM-C expression is not restricted to endothelial cells, but is also expressed on human lymphocytes.
Formulation PBS
State: Purified
State: Liquid 0.2 µm filtered Ig fraction
Stabilizer: 0.1% bovine serum albumin
Concentration 0.1 mg/ml
Purification Protein G
Gene Name junction adhesion molecule 3
Background JAM-C is a transmembrane protein which is a member of the immunoglobulin superfamily found at intercellular junctions of endothelial cells. JAM-C belongs together with JAM-A (JAM or JAM-1) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-C is potentially involved in the junctional sealing of the vascular endothelium, in particular of high endothelial venules (HEV). In adult murine tissue JAM-C expression is reported to be restricted to high endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells in kidney.
Synonyms FLJ14529; JAM-2; JAM-3; JAM-C; JAMC
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.