Clara cell protein (CC16) Mouse Monoclonal Antibody [Clone ID: AY1E6]

CAT#: AM26360PU-N

Clara cell protein (CC16) mouse monoclonal antibody, clone AY1E6, Purified

Specifications

Product Data

• Clone Name: AY1E6
• Applications: ELISA, IHC, WB
• Recommended Dilution: Immunohistochemistry on frozen sections: The typical starting working dilution is 1:50.
  Immunohistochemistry on paraffin sections: The typical starting working dilution is 1:50.
  Immunoassays.
  Western blot: The typical starting working dilution is 1:50.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Specificity:

  The monoclonal antibody AY1E6 recognizes the anti-inflammatory mediator Clara cell protein (CC16).

• Formulation: PBS
  State: Purified
  State: Liquid 0.2 µm filtered Ig fraction
  Stabilizer: 0.1% BSA
  Preservative: 0.02% sodium azide
• Concentration: 0.1 mg/ml
• Purification: Protein G Chromatography
• Background: Clara cell protein or urinary protein 1 is a homodimeric protein of 16 kD and is secreted predominantly by Clara cells in terminal bronchioles and from puberty on in the male urogenital tract. CC16 is formed by two chains, each with a molecular weight of 7.9 kD. CC16 occurs in very high concentrations in respiratory tract derived fluids such as sputum or bronchoalveolar lavage fluid. CC16 occurs also in urogenital secretions, such as amniotic fluid, urine and semen. The protein difusses passively into serum. CC16 behaves like an anti-cytokine by downregulating the production of IFN-gamma, IL-1 and TNF-alpha by stimulated leukocytes. Besides this, CC16 reduces the antiviral activity and the augmentation of phagocytosis induced by IFN-gamma.
• Synonyms: Urinary protein 1