IL1RA (IL1RN) (IL-1ra3) Mouse Monoclonal Antibody [Clone ID: 2D11]

CAT#: AM26365PU-N

IL1RA (IL1RN) (IL-1ra3) mouse monoclonal antibody, clone 2D11, Purified

Specifications

Product Data

• Clone Name: 2D11
• Applications: ELISA, IHC, WB
• Recommended Dilution: Immunohistochemistry on frozen sections: The typical starting working dilution is 1:10.
  Immunoassays.
  Western blot: The typical starting working dilution is 1:10.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Specificity:
  The antibody reacts specificly with Human IL-1ra3. Other species not tested.
• Formulation: PBS
  State: Purified
  State: Liquid 0.2 µm filtered Ig fraction
  Stabilizer: 0.1% bovine serum albumin
  Preservative: 0.02% sodium azide
• Concentration: lot specific
• Purification: Protein G
• Storage: Store at 2 - 8 °C.
  
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 3557 Human
• Background: IL-1ra3 belongs to the IL-1 system which includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. Three molecular isoforms of the IL-1 receptor antagonist (IL-1ra) have been identified and cloned. Secreted IL-1ra (sIL-1ra or IL-1ra1) contains a classical leader peptide giving a released mature protein. Two intracellular isoforms, icIL-1ra type I (IL-1ra2) and icIL-1 ra type II (IL-1ra3), have no leader sequence, thus predicting that these proteins remain intracellular. IL-1ra3 may represent a reservoir of IL-1 inhibitors, released upon cell death, whose function is to limit the pro-inflammatory action of cell debris. Studies have shown that IL-1ra3 is expressed by various cell types upon exposure to inflammatory signals but most prominently by mononuclear phagocytes and keratinocytes.
• Synonyms: IL1F3, IL-1ra, IL-1RN, IRAP, IL1 inhibitor, ICIL-1RA