HLA DM (HLA-DMA) Rat Monoclonal Antibody [Clone ID: M5/114]

CAT#: AM26699FC-N

HLA DM (HLA-DMA) rat monoclonal antibody, clone M5/114, FITC


USD 240.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name M5/114
Applications FC
Recommended Dilution Flow Cytometry: 4 µg/ml (starting point).
Reactivities Mouse
Host Rat
Isotype IgG2b
Clonality Monoclonal
Immunogen Activated C57BL/6 mouse spleen cells
Specificity The antibody M5/114 reacts with murine MHC class II glycoproteins. It recognizes a shared determinant on I-Ab, I-Ad, I-Aq, and I-Ed, I-Ek alloantigens, but it does not react with I-Af, I-Ak, I-As. This antibody can inhibit I-A-restricted T cell responses of the H-2b, H-2d, H-2q, H-2u but not H-2f, H-2k, H-2s haplotypes.
Formulation Phosphate buffered saline (PBS), approx. pH 7.4
Label: FITC
State: Liquid purified Ig fraction
Preservative: 15 mM sodium azide
Concentration lot specific
Conjugation FITC
Storage

Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.

Stability Shelf life: one year from despatch.

Background MHC (major histocompatibility complex) class II molecules are transmembrane glycoproteins expressed on the surface of professional antigen-presenting cells, such as macrophages, dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-24 amino acid residues long.
Synonyms DMA, RING6, MHC class II antigen DMA
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.