ARHGEF4 (143-271) Mouse Monoclonal Antibody [Clone ID: ARHGEF-08]

CAT#: AM26710RP-N

ARHGEF4 (143-271) mouse monoclonal antibody, clone ARHGEF-08, PE


USD 300.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name ARHGEF-08
Applications FC, WB
Recommended Dilution Flow Cytometry.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant fragment of human ARHGEF4 (amino acids 143-271)
Specificity This antobdy recognizes Human intracellular protein ARHGEF4 / ASEF1, approx. 80 kDa guanine nucleotide exchange factor specific for Rac1 and Cdc42.
Formulation PBS
Label: PE
State: Liquid purified Ig fraction
Stabilizer: 0.2% (w/v) high-grade protease free BSA
Preservative: 15 mM Sodium Azide
Label: Conjugated with R-Phycoerythrin (PE) under optimum conditions.
Concentration 0.1 mg/ml
Purification Size Exclusion Chromatography
Conjugation PE
Background ARHGEF4 (Rho guanine nucleotide exchange factor 4), also known as ASEF 1 (adenomatous polyposis coli – stimulated guanine nucleotide exchange factor 1) is an approximately 80 kDa cytoplasmic protein important for growth factor-mediated regulation of cell morphology and migration. Besides N-terminal adenomatous polyposis coli (APC)-binding region (ABR) it contains Dbl homology (DH), Pleckstrin homology (PH) and SH3 domains. The SH3 domain inhibits GEF activity of ARHGEF4 by intramolecular interaction with the DH domain, whereas binding of APC stimulates the GEF activity. Activated ARHGEF4 stimulates the small GTPase Cdc42, which leads to decreased cell-cell adherence and enhanced cell migration.
Synonyms KIAA1112, ASEF
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.