LARGE (LARGE1) (35-142) Mouse Monoclonal Antibody [Clone ID: LARGE-02]

CAT#: AM26764RP-N

LARGE (LARGE1) (35-142) mouse monoclonal antibody, clone LARGE-02, PE

Product Images

Western blotting analysis of LARGE1 in HEK293-LARGE1 transfectants (A) and HEK293 cells (B) using mouse monoclonal antibody (clone LARGE-02).

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  Flow cytometry analysis of LARGE1 in HEK293-LARGE1 transfectants using mouse monoclonal antibody (clone LARGE-02) PE.

Specifications

Product Data

• Clone Name: LARGE-02
• Applications: FC, WB
• Recommended Dilution: Flow cytometry.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Recombinant fragment of human LARGE1 (amino acids 35-142)
• Specificity: Thisa ntibody recognizes human LARGE1, a glycosyltransferase localizing mainly to the Golgi apparatus. Crossreactivity with LARGE2 was not determined.
• Formulation: Phosphate buffered saline (PBS)
  Label: PE
  State: Liquid purified Ig fraction
  Stabilizer: 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA)
  Preservative: 15 mM sodium azide
  Label: Conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate was purified by size-exclusion chromatography.
• Conjugation: PE
• Database Link:
  Entrez Gene 9215 Human
• Background: LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.
• Synonyms: LARGE, KIAA0609, LARGE1, Glycosyltransferase-like protein LARGE1, Acetylglucosaminyltransferase-like 1A