KIR2DL5A Mouse Monoclonal Antibody [Clone ID: UP-R1]

CAT#: AM26776RP-N

KIR2DL5A mouse monoclonal antibody, clone UP-R1, PE

Product Images

Surface staining of human peripheral blood with anti-CD158f (UP-R1) PE.

Specifications

Product Data

• Clone Name: UP-R1
• Applications: FC
• Recommended Dilution: Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human CD158f-Ig fusion protein
• Specificity: This antibody recognizes CD158f (KIR2DL5), a 60 kDa glycoprotein serving as a HLA class I ligand, and mainly expressed on a subset of NK cells and a small population of T cells. Its expression is highly polymorphic between individuals.
• Formulation: Phosphate buffered saline (PBS)
  Label: PE
  State: Liquid puriified Ig fraction
  Stabilizer: 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA)
  Preservative: 15 mM sodium azide
• Conjugation: PE
• Database Link:
  Entrez Gene 57292 Human
• Background: CD158f, also known as KIR2DL5, is a polymorphic 60 kDa transmembrane glycoprotein with two Ig-like extracellular domains by which it recognize HLA class I molecules. Its long intracellular domain contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that upon extracellular ligand-mediated phosphorylation serve as docking sites for inhibitory phosphatases, which results in blocking natural cytotoxicity as well as antibody-dependent cytotoxicity of the particular NK cell, and its adhesion toward target cells. Together with other killer inhibitory receptors CD158f is important for immunological tolerance to discriminate between normal and abnormal cells. Besides NK cells it is expressed on a small population of cytotoxic T cells. Expression of CD158f alleles is highly variable in the population.
• Synonyms: CD158F1, KIR2DL5