ZNFN1A2 (IKZF2) (51-107) Hamster Monoclonal Antibody [Clone ID: 22F6]

CAT#: AM26777PU-N

ZNFN1A2 (IKZF2) (51-107) hamster monoclonal antibody, clone 22F6, Purified

Product Images

Human peripheral blood lymphocytes were stained with anti-CD4 Pacific BlueTM, fixed and permeabilized with Treg Detection Kit, and then intracellulary stained with anti-Helios PE (clone 22F6).

Specifications

Product Data

• Clone Name: 22F6
• Applications: FC
• Recommended Dilution: Flow cytometry: Intracellular staining.
• Reactivities: Human, Mouse
• Host: Hamster
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Peptide coresponding to the amino acids 51-107 of Helios
• Specificity: This antibody recognizes Helios, a transcription factor expressed in some hematopoietic stem cells, and at high levels in thymic-derived regulatory T cells.
• Formulation: Phosphate buffered saline (PBS)
  State: Purified
  State: Liquid Ig fraction
  Preservative: 15 mM sodium azide, approx. pH 7.4
• Concentration: 1.0 mg/ml
• Purification: Protein-A affinity chromatography
• Database Link:
  Entrez Gene 22807 Human
• Background: Helios, also known as IKZF2 (Ikaros family zinc finger protein 2) is a hematopoietic-specific transcription factor involved in the regulation of lymphocyte development, together with other members of this family, such as Aiolos and Ikaros. Helios forms homo- and heterodimers with these proteins and is thought to function predominantly in early hematopoietic development. Expression of Helios, Aiolos and Ikaros is restricted to cells of the hematopoietic system, whereas other family members, Eos and Pegassus, are more widely expressed. Helios is expressed at early stages of thymocyte development. In mature T cells, Helios has been strongly associated with Treg cells.
• Synonyms: helios; MGC34330; OTTHUMP00000163964; ZNF1A2; ZNFN1A2