CD2 Mouse Monoclonal Antibody [Clone ID: TS1/8]

CAT#: AM26778LE-N

CD2 mouse monoclonal antibody, clone TS1/8, PE

Specifications

Product Data

• Clone Name: TS1/8
• Applications: FC, FN
• Recommended Dilution: Flow cytometry.
  Functional application: Blocking.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Cytotoxic T lymphocytes
• Specificity: This antibody recognizes CD2, a 50 kDa glycoprotein present on the human peripheral blood T lymphocytes and NK cells; also expressed by all thymocytes.
• Formulation: Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized
  Label: PE
  State: Liquid Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Protein-A affinity chromatography
• Conjugation: PE
• Background: CD2 (also known as LFA-2) belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.