TNFSF12-TNFSF13 Mouse Monoclonal Antibody [Clone ID: CARL-1]

CAT#: AM26783PU-N

TNFSF12-TNFSF13 mouse monoclonal antibody, clone CARL-1, Purified

Specifications

Product Data

• Clone Name: CARL-1
• Applications: FC, FN
• Recommended Dilution: Flow cytometry.
  Functional application: Neutralization.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG3
• Clonality: Monoclonal
• Immunogen: Human CD255-transfected 2PK-3 cells
• Specificity: This antobody recognizes CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to weakly induce apoptosis in many cell types.
• Formulation: Phosphate buffered saline (PBS)
  State: Purified
  State: Liquid Ig fraction
  Preservative: 15 mM sodium azide, approx. pH 7.4
• Concentration: 1.0 mg/ml
• Purification: Protein-A affinity chromatography
• Database Link:
  Entrez Gene 407977 Human
• Background: CD255 / TWEAK (TNF-related weak inducer of apoptosis), a type II transmembrane protein expressed as membrane-bound and secreted form, can induce apoptosis in many tissues and cell lines through its receptor CD266 / TWEAK R. On the other hand, in endothelial cells this interaction can induce proliferation and promote angiogenesis including neovascularization of tumours. CD255 can act in a juxtacrine manner to initiate cellular responses, and induces secretion of pro-inflammatory cytokines. Besides CD266, CD255 may also bind to DR3.
• Synonyms: APO3 ligand, APO3L, DR3LG