CD193 / CCR3 Mouse Monoclonal Antibody [Clone ID: 5E8]

CAT#: AM26800RP-N

CD193 / CCR3 mouse monoclonal antibody, clone 5E8, PE

Product Images

Surface staining of CD193 in human peripheral blood with anti-human CD193 (5E8) PE.

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  Surface staining of CD193 in human peripheral blood with anti-human CD193 (5E8) APC.

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  Surface staining of CD193 in human peripheral blood with anti-human CD193 (5E8) purified, GAM-APC.

Specifications

Product Data

• Clone Name: 5E8
• Applications: FC
• Recommended Dilution: Flow Cytometry analysis of human blood cells using 10 ?l reagent / 100 ?l of whole blood or 10⁶ cells in a suspension.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Specificity: This antibody clone 5E8 recognizes CD193 (chemokine receptor 3), an approximately 41 kDa protein expressed above all in eosinophils and basophils.
• Formulation: Phosphate buffered saline (PBS) containing 15 mM sodium azide
  Label: PE
  State: Liquid purified Ig fraction
  Label: Conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
• Conjugation: PE
• Background: CD193 / CCR3 is a G-protein coupled receptor for several chemokines, namely CCL11 (eotaxin), CCL26 (eotaxin-3), CCL7 (MCP-4), or CCL5 (RANTES). It is highly expressed on eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. CD193 is the key eosinophil chemokine receptor responsible for regulation of eosinophil migration and function. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1.
• Synonyms: C-C chemokine receptor type 3, C-C CKR-3, CC-CKR-3, CCR-3, CKR3, CMKBR3