NR2C2 Mouse Monoclonal Antibody [Clone ID: 2A5]

CAT#: AM31015PU-N

NR2C2 mouse monoclonal antibody, clone 2A5, Purified

Product Images

Western Blot analysis of NR2C2 expression in transfected 293T cell line by NR2C2 monoclonal antibody clone 2A5.

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  Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 2A5
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: NR2C2 antibody was raised against recombinant protein
• Specificity: This antibody reacts to NR2C2.
• Formulation: PBS, pH 7.2
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A chromatography
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens nuclear receptor subfamily 2 group C member 2 (NR2C2), transcript variant 1
• Database Link:
  Entrez Gene 7182 Human
• Background: TR4 is a NR2 Hepatocyte NF4-Like nuclear hormone receptor and transcription factor related to the orphan receptors TR2, COUP-TFI, and ARP-1. TR4 has been shown to affect the proliferation and maturation of brain structures, neurogenesis, the regulation of myeloid progenitor cell proliferation and development, and retinoid-mediated signaling pathways. TR4 binds to target DNA as a homodimer or a monomer, and has been shown to affect transcription of ciliary neurotrophic factor receptor (CNTFR alpha), luteinizing hormone receptor, and human steroid 21-hydroxylase genes. During development, the expression of TR4 in human and rat brain correlates with the progression of neuronal maturation. TR4 becomes progressively restricted to the hypothalamus and cerebellum in older embryos and adults. Recently, it has been shown that TR4 can suppress estrogen receptor function via direct protein-protein interaction. Three rat and two human TR4 mRNA splice variants have been documented.
• Synonyms: TAK1, TR4

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors