SGK1 Mouse Monoclonal Antibody [Clone ID: 3G8]

CAT#: AM31034PU-N

SGK1 mouse monoclonal antibody, clone 3G8, Purified


USD 480.00

2 Weeks*

Size
    • 50 ug

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Specifications

Product Data
Clone Name 3G8
Applications ELISA, IF, IHC, WB
Recommended Dilution ELISA.
Immunofluorescence: 10 µg/ml.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Western Blot.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen SGK (AAH01263, 1 a.a. ~ 91 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity This antibody recognizes SGK1.
Formulation PBS, pH 7.2
State: Purified
State: Liquid purfied Ig fraction
Concentration 0.29 mg/ml
Purification Protein A chromatography
Gene Name Homo sapiens serum/glucocorticoid regulated kinase 1 (SGK1), transcript variant 2
Background SGK, a SGK type protein kinase, is a multi-functional kinase that is phosphorylated and activated through a 3-phosphoinositide-dependent protein kinase 1 (PDK1) signaling pathway. The protein has been shown to activate certain potassium, sodium and chloride channels which function in cell survival, neuronal excitability and renal sodium excretion. SGK transcription can be stimulated by glucocorticoids, aldosterone, TGF-beta1, serum, increase of intracellular Ca2+ and phorbolesters, and can be downregulated by cAMP. At least 2 mRNA variants have been reported. The SGK1 gene has been mapped to chromosome 6q23, a region frequently affected by deletion in various human neoplasms, and has been shown to be upregulated in lung fibrosis, diabetic nephropathy and chronic viral hepatitis.
Synonyms Serine/threonine-protein kinase Sgk1
Reference Data
Protein Families Druggable Genome, Protein Kinase

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.