SGK1 Mouse Monoclonal Antibody [Clone ID: 3G8]

CAT#: AM31034PU-N

SGK1 mouse monoclonal antibody, clone 3G8, Purified

Product Images

Detection limit for recombinant GST tagged SGK is approximately 0.1ng/ml as a capture antibody.

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  Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Immunofluorescence of monoclonal antibody to SGK1 on HeLa cell. [antibody concentration 10 ug/ml]

Specifications

Product Data

• Clone Name: 3G8
• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA.
  Immunofluorescence: 10 µg/ml.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: SGK (AAH01263, 1 a.a. ~ 91 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Specificity: This antibody recognizes SGK1.
• Formulation: PBS, pH 7.2
  State: Purified
  State: Liquid purfied Ig fraction
• Concentration: 0.29 mg/ml
• Purification: Protein A chromatography
• Gene Name: Homo sapiens serum/glucocorticoid regulated kinase 1 (SGK1), transcript variant 2
• Database Link:
  Entrez Gene 6446 Human
• Background: SGK, a SGK type protein kinase, is a multi-functional kinase that is phosphorylated and activated through a 3-phosphoinositide-dependent protein kinase 1 (PDK1) signaling pathway. The protein has been shown to activate certain potassium, sodium and chloride channels which function in cell survival, neuronal excitability and renal sodium excretion. SGK transcription can be stimulated by glucocorticoids, aldosterone, TGF-beta1, serum, increase of intracellular Ca2+ and phorbolesters, and can be downregulated by cAMP. At least 2 mRNA variants have been reported. The SGK1 gene has been mapped to chromosome 6q23, a region frequently affected by deletion in various human neoplasms, and has been shown to be upregulated in lung fibrosis, diabetic nephropathy and chronic viral hepatitis.
• Synonyms: Serine/threonine-protein kinase Sgk1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase