SMC1 (SMC1A) Mouse Monoclonal Antibody [Clone ID: 1B9]

CAT#: AM31080PU-N

SMC1 (SMC1A) mouse monoclonal antibody, clone 1B9, Purified

Product Images

Detection limit for recombinant GST tagged SMC1L1 is approximately 0.03ng/ml as a capture antibody.

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  Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 1B9
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: SMC1A antibody was raised against recombinant protein
• Specificity: This antibody reacts to SMC1A / SMC1.
• Formulation: PBS, pH 7.2
  State: Purified
  State: Liquid purfied Ig fraction
• Concentration: 0.33 mg/ml
• Purification: Protein A chromatography
• Gene Name: Homo sapiens structural maintenance of chromosomes 1A (SMC1A), transcript variant 1
• Database Link:
  Entrez Gene 8243 Human
• Background: Structural maintenance of chromosome proteins (SMC) are involved in chromosome cohesion during cell cycle and in DNA repair as part of the of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint The form of SMC1A phosphorylated at Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function.
• Synonyms: SMC protein 1A, SMC-1A, SMC-1-alpha, SMC1L1, DXS423E

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Cell cycle, Oocyte meiosis