HIPK2 Mouse Monoclonal Antibody [Clone ID: 1F10]

CAT#: AM31106PU-N

HIPK2 mouse monoclonal antibody, clone 1F10, Purified

Product Images

Western Blot analysis of HIPK2 expression in MES-SA/Dx5 cells with HIPK2 monoclonal antibody, clone 1F10.

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  Western Blot analysis of HIPK2 expression in RIN-m5F cells with HIPK2 monoclonal antibody, clone 1F10.

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  Detection limit for recombinant GST tagged HIPK2 is approximately 0.1ng/ml as a capture antibody.

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  Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 1F10
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human, Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: HIPK2 antibody was raised against recombinant protein
• Specificity: This antibody reacts to HIPK2.
• Formulation: PBS, pH 7.2
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Affinity chromatography on Protein A
• Gene Name: Homo sapiens homeodomain interacting protein kinase 2 (HIPK2), transcript variant 2
• Database Link:
  Entrez Gene 362342 RatEntrez Gene 28996 Human
• Background: HIPK2, a nuclear serine/threonine kinase similar to the MNB/DYRK type protein kinases, represses transcription mediated by homeodomain containing transcription factors. HIPK2 is activated by ultraviolet (UV) radiation and selectively phosphorylates p53 to promote p53-dependent gene expression. HIPK2 interacts with various proteins, including members of the p53 family, to regulate cell cycle and apoptosis. Variants of HIPK2 have been observed due to alternative splicing.
• Synonyms: DKFZp686K02111; FLJ23711; hHIPk2; PRO0593

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transcription Factors