Natriuretic Peptide Receptor B (NPR2) (131-231) Mouse Monoclonal Antibody [Clone ID: 2A6]

CAT#: AM31133PU-N

Natriuretic Peptide Receptor B (NPR2) (131-231) mouse monoclonal antibody, clone 2A6, Purified

Product Images

Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 2A6
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: NPR2 antibody was raised against nPR2 (-, 131 a.a. ~ 231 a.a) partial recombinant protein with GST tag.
• Specificity: This antibody reacts to Human NPR2 at aa 131-231.
• Formulation: PBS, pH 7.4
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens natriuretic peptide receptor 2 (NPR2)
• Database Link:
  Entrez Gene 4882 Human
• Background: NPR2 encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, an intracellularly a protein kinase homology domain, an helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. NPR2 is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity.
• Synonyms: ANP-B, ANP receptor B, GC-B, Guanylate cyclase B, NPR-B, Atrial natriuretic peptide B-type receptor

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Purine metabolism, Vascular smooth muscle contraction