DMT1 (SLC11A2) (1-66) Mouse Monoclonal Antibody [Clone ID: 4C6]

CAT#: AM31134PU-N

DMT1 (SLC11A2) (1-66) mouse monoclonal antibody, clone 4C6, Purified

Product Images

Detection limit for recombinant GST tagged SLC11A2 is 0.03 ng/ml as a capture antibody.

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  Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 4C6
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: sLC11A2 (NP_000608, 1 a.a. ~ 66 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Specificity: This antibdoy recognizes SLC11A2 at aa 1-66.
• Formulation: PBS, pH 7.4
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A purified
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 (SLC11A2), transcript variant 4
• Database Link:
  Entrez Gene 4891 Human
• Background: Solute carrier family 11, member 2 (SLCA2) also known as divalent metal ion transporter 1 (DMT1) imports Fe2+ via a proton-coupled, membrane potential dependent manner. It can also transport a variety of other divalent metal cations including Mn2+, Co2+, Cu2+, and Zn2+ but iron appears to be its most important physiological substrate. SLC11A2 has been demonstrated on the apical membrane of duodenal enterocytes, transferrin cycle endosomes in erythroid precursors, hepatocytes where it has been postulated to be involved in non-transferrin-bound iron uptake, and placenta where it has been implicated in transfer of iron from mother to fetus.
• Synonyms: NRAMP-2, DCT1, DMT1, DMT-1

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Lysosome