CD130 (IL6ST) Mouse Monoclonal Antibody [Clone ID: B-P4]
Other products for "IL6ST"
Specifications
Product Data | |
Clone Name | B-P4 |
Applications | FC, FN, IHC, IP, WB |
Recommended Dilution | Western Blot. Immunoprecipitation. Flow Cytometry. Functional Assay: Inhibits IL-11 activity and binding to gp130, but not CNTF, LIF and OSM activities. Immunohistochemistry (Reported in Publications). |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Natural soluble gp130. Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells. |
Specificity | Recognizes the soluble antigen. Recognizes the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein. |
Formulation | Phosphate-buffered saline without carrier and preservatives. This prodcut is sterile-filtered through 0.22 µm. State: Azide Free State: Liquid purified IgG fraction |
Concentration | lot specific |
Purification | Ion Exchange Chromatography |
Storage | Store the antibody undiluted at 2-8°C. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens interleukin 6 signal transducer (IL6ST), transcript variant 1 |
Database Link | |
Background | IL-6 activates intracellular signaling through binding a receptor consisting of an 80 kDa ligand-binding protein (IL-6R) and a second protein of 130 kDa. IL-6 first binds to IL-6R which subsequently associates with a gp130 dimer. The active signaling complex consists of at minimum IL-6, IL-6R and a dimer of two gp130 proteins that are linked by a disulfide bond. A soluble form of IL-6R is generated by proteolytic cleavage of the membrane-bound precursor and can function as an agonistic molecule that can actively participate in cell-tocell signaling. The second subunit of the IL-6 complex, gp130, also functions as a component of several additional receptor complexes including leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11. LIF binds to the LIF receptor with low affinity and to a complex of the LIF receptor and gp130 with high affinity, while OSM appears to bind to gp130 with low affinity and to a complex of gp130 and the LIF receptor with high affinity. |
Synonyms | Interleukin-6 receptor subunit beta, IL-6R-beta, IL6 receptor beta |
Reference Data | |
Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
Protein Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
Documents
Product Manuals |
FAQs |
{0} Product Review(s)
0 Product Review(s)
Submit review
Be the first one to submit a review
Product Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.