VCAM1 Mouse Monoclonal Antibody [Clone ID: B-K9]

CAT#: AM31190AF-N

VCAM1 mouse monoclonal antibody, clone B-K9, Azide Free

Product Images

A typical staining pattern with the B-K9 monoclonal antibody of VCAM-1 transfected CHO cell line.

Specifications

Product Data

• Clone Name: B-K9
• Applications: ELISA, FC, FN
• Recommended Dilution: ELISA.
  Flow Cytometry.
  Functional Assay: Blocks the cell attachment to VCAM-1.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Activated Human umbilical vein endothelial.
  cells.
  Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells.
• Specificity: Recognizes the Vascular Cellular Adhesion Molecule-1 (VCAM-1), a 110 kDa protein.
  Recognizes the soluble antigen.
• Formulation: Phosphate-buffered saline without Carrier and preservatives.
  This prodcut is sterile-filtered through 0.22 µm and treated to remove Endotoxins.
  State: Azide Free
  State: Liquid purified IgG fraction.
• Concentration: lot specific
• Purification: Ion Exchange Chromatography.
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens vascular cell adhesion molecule 1 (VCAM1), transcript variant 1
• Database Link:
  Entrez Gene 7412 Human
• Background: CD106 / VCAM-1 (vascular cell adhesion molecule-1) is an Ig-like cell surface adhesion molecule binding VLA-4 integrin. VCAM-1 is a potent T cell costimulatory molecule taking
  part in their positive selection and survival, as well as in adhesion, transendothelial migration and activation of peripheral T cells. VCAM-1 is also involved in endothelial cell-cell contacts.
  Whereas VCAM-1 normally mediates leukocyte extravasion to sites of tissue inflammation, tumour cells can use overexpressed VCAM-1 to escape T cell immunity. Soluble form of VCAM-1 (sVCAM-1) is an inflammatory marker and can be used also in prognosis of subsequent cariovascular events following acute coronary syndromes.
• Synonyms: V-CAM 1, INCAM-100, L1CAM, VCAM-1

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration