CXCR4 Mouse Monoclonal Antibody [Clone ID: B-R24]

CAT#: AM31204PU-N

CXCR4 mouse monoclonal antibody, clone B-R24, Purified


USD 250.00

2 Weeks*

Size
    • 2 ml (200 Tests)

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Specifications

Product Data
Clone Name B-R24
Applications FC
Recommended Dilution Flow Cytometry: Use 10 µl to label 10e6 cells or 100 µl of whole blood.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen CXCR4 transfected CHO cell line.
Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells.
Specificity Recognizes the soluble antigen.
Recognizes the CXCR4 antigen, a 39.7 kDa protein.
Formulation PBS containing 1% BSA as stabilizer and 0.09% Sodium Azide as preservative
State: Purified
State: Liquid purified IgG fraction.
Purification Ion Exchange Chromatography.
Gene Name Homo sapiens chemokine (C-X-C motif) receptor 4 (CXCR4), transcript variant 1
Background CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T cell tropic strains of HIV1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual tropic strains of HIV1 and mediates CD4 independent infection by HIV2. The a chemokine SDF1 is the ligand for CXCR4 and prevents infection by T tropic HIV1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV1 and HIV2 fusion and infection of human target cells. The amino terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites. CXCR4 is highly expressed in brain and heart, and in white blood cells, vascular endothelial cells, and umbilical cord endothelial cells.
Synonyms CXC-R4, CXCR-4, Fusin, LCR1, FB22, NPYRL, HM89, SDF1 receptor, LESTR
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane
Protein Pathways Axon guidance, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis, Leukocyte transendothelial migration

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.