DcR1 (TNFRSF10C) Mouse Monoclonal Antibody [Clone ID: B-D44]

CAT#: AM31207PU-N

DcR1 (TNFRSF10C) mouse monoclonal antibody, clone B-D44, Purified

Specifications

Product Data

• Clone Name: B-D44
• Applications: FC
• Recommended Dilution: Flow Cytometry: Use 10 µl to label 10e6 cells or 100 µl of whole blood.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human TRAIL R3/Fc chimera.
  Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells.
• Specificity: Recognizes the soluble antigen.
  Recognizes the 75-90kDa protein.
• Formulation: PBS containing 1% BSA as stabilizer and 0.09% Sodium Azide as preservative.
  State: Purified
  State: Liquid purified IgG fraction.
• Purification: Ion Exchange Chromatography.
• Gene Name: Homo sapiens tumor necrosis factor receptor superfamily member 10c (TNFRSF10C)
• Database Link:
  Entrez Gene 8794 Human
• Background: TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5).
• Synonyms: Decoy receptor 1, TNFRSF10C, DCR1, LIT, TRID, TRAIL receptor 3, TRAIL-R3

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity