IL7 Mouse Monoclonal Antibody [Clone ID: B-S16]

CAT#: AM31208AF-N

IL7 mouse monoclonal antibody, clone B-S16, Azide Free

Specifications

Product Data

• Clone Name: B-S16
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human IL7.
• Specificity: Recognizes the soluble antigen.
  Recognizes both natural and recombinant Human IL-7.
• Formulation: Phosphate-buffered saline without Carrier and preservatives.
  This prodcut is sterile-filtered through 0.22 µm and treated to remove Endotoxins.
  State: Azide Free
  State: Liquid purified IgG fraction.
• Concentration: lot specific
• Purification: Ion Exchange Chromatography.
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens interleukin 7 (IL7), transcript variant 1
• Database Link:
  Entrez Gene 3574 Human
• Background: Interleukin 7 (IL7) is a lymphoid cell growth factor that affects pre-B, pro-B, and early T cells. IL7 was previously known as pre-B cell growth factor and lymphopoietin 1. IL7 supports the growth of early B cells from long-term lymphoid bone marrow cultures. It is mitogenic to thymocytes and enhances the response of cells to other stimuli such as polyhydroxyalkanoate (PHA) and concanavalin A (ConA). IL7 stimulates the proliferation of CD4+/CD8+ cells. The proliferative response of thymocytes to IL7 is not affected by antibodies to the T cell growth factors such as IL2, IL4 and IL6, suggesting that IL7 is capable of stimulating T cell proliferation through a pathway independent of the known T cell growth factors. Mature T cells respond to IL7 and Con A, but not to IL7 alone. In myeloid lineage cells, IL7 upregulates the production of pro-inflammatory cytokines and stimulates the tumoricidal activity of monocytes/macrophages. IL7 is expressed by adherent stromal cells from various tissues.
• Synonyms: IL-7

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway