IL23 (IL23A) Mouse Monoclonal Antibody [Clone ID: B-Z23]

CAT#: AM31213AF-N

IL23 (IL23A) mouse monoclonal antibody, clone B-Z23, Azide Free

Product Images

Labelling on Paraffin Section from psoriasis lesions with IL23 Antibody Clone B-Z23 diluted at 1/500 (background colouration by DAPI).

Specifications

Product Data

• Clone Name: B-Z23
• Applications: FN, IHC
• Recommended Dilution: Functional Assays: Neutralises the bioactivity of rhIL-23 on Mouse splenocytes C57BI/6 (measurement of mIL-17 or mIL-22 production).
  Immunohistochemistry on Paraffin Embedded Sections.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human IL-23 (sub-unit p19)
• Specificity: This antibody recognizes both recombinant and natural IL-23, p19 sub-unit.
• Formulation: Phosphate-buffered saline.
  Sterile-filtered through 0.22 µm and treated to remove endotoxins.
  Carrier and preservative free.
  State: Azide Free
  State: Liquid purfied IgG fraction
• Concentration: 1.0 mg/ml
• Purification: Ion Exchange Chromatography
• Gene Name: Homo sapiens interleukin 23 subunit alpha (IL23A)
• Database Link:
  Entrez Gene 51561 Human
• Background: The p19 shares sequence similarity with IL-6 subfamily members and is distantly related to the p35 subunit of IL-12. It shows no biological activity by itself; instead, it combines with the p40 subunit of IL-12 to form a biologically active, composite cytokine, IL-23. IL-23 shares some in vivo functions with IL-12, including the activation of the transcription factor Stat4. Similar to IL-12, human IL-23 stimulates IFN-g production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death.
• Synonyms: IL-23 subunit alpha, SGRF, Interleukin-23 subunit p19, IL-23p19

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway