CD40 Mouse Monoclonal Antibody [Clone ID: B-B20]

CAT#: AM31223AF-N

CD40 mouse monoclonal antibody, clone B-B20, Azide Free


USD 270.00

2 Weeks*

Size
    • 200 ug

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Specifications

Product Data
Clone Name B-B20
Applications FC, FN, IHC
Recommended Dilution Flow cytometry.
Functional Assay:
Stimulates B-cell proliferation together with IL-4. 
Immunochemistry on Frozen Sections.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Raji cell line.
Specificity This antibody recognises the Bp50 antigen, a 48 kDa protein.
Formulation Phosphate-buffered saline.
Sterile-filtered through 0.22 µm.
Carrier and preservative free.
State: Azide Free
State: Liquid purified IgG fraction
Concentration lot specific
Purification Ion Exchange Chromatography
Storage Store the antibody undiluted at 2-8°C.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens CD40 molecule (CD40), transcript variant 1
Background CD40 is a costimulatory molecule of the TNF receptor superfamily and is expressed on many cell types, such as B cells, monocytes/macrophages, dendritic cells, endothelial cells, fibroblasts or vascular smooth muscle cells. Interaction of CD40 and its ligand CD154 (CD40L) is required for the generation of antibody responses to T-dependent antigens as well as for the development of germinal centers and memory B cells. In monocytes/macrophages CD40 engagement induces production of pro-inflammatory cytokines and chemokines. CD40-CD154 interactions are also critical for development of CD4 T cell-dependent effector functions. CD40 links innate and adaptive immune responses to bacterial stimuli and serves as an important regulator affecting functions of other costimulatory molecules.
Synonyms TNFRSF5, CDw40, Bp50
Reference Data
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Allograft rejection, Asthma, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Cytokine-cytokine receptor interaction, Primary immunodeficiency, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Viral myocarditis

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.