IL2 Mouse Monoclonal Antibody [Clone ID: B-G5]

CAT#: AM31260AF-N

IL2 mouse monoclonal antibody, clone B-G5, Azide Free

Specifications

Product Data

• Clone Name: B-G5
• Applications: FC, FN, WB
• Recommended Dilution: Western Blot.
  Functional Assay: Blocks IL-2 induced proliferation on CTL-L2 murine cell line.
  Flow Cytometry (Intra-cytoplasmic).
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Natural Human IL-2
• Specificity: Recognizes both natural and recombinant Human Interleukin-2 (IL-2).
• Formulation: PBS without Carrier and preservatives.
  This product is Sterile-filtered through 0.22 µm and treated to remove endotoxins.
  State: Azide Free
  State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Ion Exchange Chromatography
• Storage: Store the antibody undiluted at 2-8°C.
  DO NOT FREEZE!
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens interleukin 2 (IL2)
• Database Link:
  Entrez Gene 3558 Human
• Background: Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells.
• Synonyms: IL-2, TCGF

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, T cell receptor signaling pathway, Type I diabetes mellitus