IL27 Mouse Monoclonal Antibody [Clone ID: B-G49]

CAT#: AM31269AF-N

IL27 mouse monoclonal antibody, clone B-G49, Azide Free


USD 470.00

2 Weeks*

Size
    • 500 ug

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Specifications

Product Data
Clone Name B-G49
Applications FC
Recommended Dilution Flow Cytometry on Dendritic cells.
Reactivities Human
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Recombinant Human IL-27.
Specificity Recognizes both natural and recombinant Human IL-27
Formulation Phosphate-buffered saline without Carrier and preservatives.
This prodcut is sterile-filtered through 0.22 µm and treated to remove Endotoxins.
State: Azide Free
State: Liquid purified IgG fraction
Concentration 1.0 mg/ml
Purification Ion Exchange Chromatography
Gene Name Homo sapiens interleukin 27 (IL27)
Background Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet.
Synonyms IL-27 subunit alpha, IL27-A, p28, IL30, IL-30, Interleukin-30
Reference Data
Protein Families Druggable Genome, Transmembrane

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.