CD62P (SELP) Mouse Monoclonal Antibody [Clone ID: B-F46]

CAT#: AM31273PU-N

CD62P (SELP) mouse monoclonal antibody, clone B-F46, Purified

Product Images

A typical staining pattern with the B-F46 monoclonal antibody of platelets.

Specifications

Product Data

• Clone Name: B-F46
• Applications: FC
• Recommended Dilution: Flow Cytometry: Use 10 µl to label 10e6 cells or 100 µl of whole blood.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human CD62P
• Specificity: This antibody recognises CD62P, a 140 kD single chain type I transmembrane glycoprotein present in secretory alpha-granules in platelets, Weibel-Palade bodies in endothelial cells and megakaryocytes.
• Formulation: Phosphate buffered saline containing 1% BSA as stabilizer and 0.09% Sodium Azide as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Purification: Ion Exchange Chromatography
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens selectin P (SELP)
• Database Link:
  Entrez Gene 6403 Human
• Background: CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and endothelial cells upon their activation. Interaction between CD62P and its mucin-like ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembrane domains and stabilizes leukocyte tethering and rolling, probably by increasing rebinding within a bond cluster.
• Synonyms: SELP, GMRP, GRMP, PADGEM, GMP-140, LECAM3

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)