CD130 (IL6ST) Mouse Monoclonal Antibody [Clone ID: B-R3]

CAT#: AM31350AF-N

CD130 (IL6ST) mouse monoclonal antibody, clone B-R3, Azide Free

Product Images

A typical staining pattern with the B-R3 monoclonal antibody of Eahy 926 cell line.

Specifications

Product Data

• Clone Name: B-R3
• Applications: FC, FN
• Recommended Dilution: Flow Cytometry.
  Functional Assay:
  Inhibits IL-6, IL-11, CNTF, LIF and OSM activities.
  Inhibits OSM and CNTF binding to gp130.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Natural soluble gp130.
• Specificity: Recognises the soluble antigen.
  Recognises the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein.
• Formulation: PBS, Sterile-filtered through 0.22 µm and treated to remove endotoxins.
  Carrier and preservative free
  State: Azide Free
  State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Ion Exchange Chromatography
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens interleukin 6 signal transducer (IL6ST), transcript variant 1
• Database Link:
  Entrez Gene 3572 Human
• Background: CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
• Synonyms: Interleukin-6 receptor subunit beta, IL-6R-beta, IL6 receptor beta

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway