CD130 (IL6ST) Mouse Monoclonal Antibody [Clone ID: B-R3]

CAT#: AM31350PU-N

CD130 (IL6ST) mouse monoclonal antibody, clone B-R3, Purified


USD 250.00

2 Weeks*

Size
    • 2 ml (200 Tests)

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Specifications

Product Data
Clone Name B-R3
Applications FC
Recommended Dilution Flow Cytometry: Use 10 µl to label 10e6 cells in 100 µl of whole blood.
Reactivities Human
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Natural soluble gp130.
Specificity Recognises the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein.
Formulation PBS containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer
State: Purified
State: Liquid purified IgG fraction
Purification Ion Exchange Chromatography
Storage Store the antibody undiluted at 2-8°C.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens interleukin 6 signal transducer (IL6ST), transcript variant 1
Background CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Synonyms Interleukin-6 receptor subunit beta, IL-6R-beta, IL6 receptor beta
Reference Data
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.