IL6 Mouse Monoclonal Antibody [Clone ID: B-E8]

CAT#: AM31351RP-N

IL6 mouse monoclonal antibody, clone B-E8, PE

Specifications

Product Data

• Clone Name: B-E8
• Applications: FC
• Recommended Dilution: Flow Cytometry (Intra-cytoplasmic): Use 10 µl of antibody to label 5x10⁵ cells.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human recombinant IL-6.
• Specificity: Recognises both natural and recombinant Human IL-6
• Formulation: PBS with 5% BSA and 0.09% Sodium Azide
  Label: PE
  State: Lyophilized purified IgG fraction
• Reconstitution Method: Restore with 1 ml deionized water.
• Purification: Ion Exchange Chromatography
• Conjugation: PE
• Storage: Store the antibody undiluted at 2-8°C after reconstitution.
  DO NOT FREEZE!
• Stability: Shelf life: Six months from despatch.
• Gene Name: Homo sapiens interleukin 6 (IL6), transcript variant 1
• Database Link:
  Entrez Gene 3569 Human
• Background: Interleukin 6 (IL6) is a multifunctional 24 kDa protein originally discovered in the medium of RNA stimulated fibroblastoid cells. It is upregulated by IL1, TNF, PDGF, IFN beta, TNF alpha, NGF, IL17 and downregulated by glucocorticoids IL4, TGF beta. IL6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be as important as IL1 and TNF alpha in regulating the acute phase response. IL6 has also been implicated in regulating adipose mass.
• Synonyms: IL-6, Interferon beta-2, IFNB2, B-cell stimulatory factor 2, BSF-2, CDF

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Jak-STAT signaling pathway, NOD-like receptor signaling pathway, Pathways in cancer, Prion diseases, Toll-like receptor signaling pathway