IL8 (CXCL8) Mouse Monoclonal Antibody [Clone ID: B-K8]

CAT#: AM31352RP-N

IL8 (CXCL8) mouse monoclonal antibody, clone B-K8, PE

Specifications

Product Data

• Clone Name: B-K8
• Applications: FC
• Recommended Dilution: Flow Cytometry (Intra-cytoplasmic): Use 10µl of antibody to label 5x10e5 cells.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Human IL-8
• Specificity: Recognises both natural and recombinant IL-8.
• Formulation: PBS with 5% BSA and 0.09% Sodium Azide
  Label: PE
  State: Lyophilized purified IgG fraction
• Reconstitution Method: Restore with 1 ml deionized water
• Purification: Ion Exchange Chromatography
• Conjugation: PE
• Storage: Store the antibody undiluted at 2-8°C after reconstitution.
  DO NOT FREEZE!
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens chemokine (C-X-C motif) ligand 8 (CXCL8)
• Database Link:
  Entrez Gene 3576 Human
• Background: IL8 is a member of the CXC chemokine family. This family of small basic heparan-binding proteins are proinflammatory and primarily mediate the activation and migration of neutrophils into tissue from peripheral blood.
  This chemokine is one of the major mediators of the inflammatory response and is secreted by several cell types in response to an inflammatory stimulus. It functions as a chemoattractant, and is also a potent angiogenic factor. IL8 attracts neutrophils, basophils, and T-cells, but not monocytes.
  Cystic fibrosis (CF) is characterized by severe lung inflammation. The inflammatory process is believed to be caused by massive overproduction of the proinflammatory protein IL8, and the high levels of IL8 in the CF lung are therefore believed to be the central mechanism behind CF lung pathophysiology.
• Synonyms: CXCL8, Protein 3-10C, Emoctakin, GCP1, MDNCF, MONAP, NAP1

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Bladder cancer, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway