Thrombomodulin (THBD) Mouse Monoclonal Antibody [Clone ID: B-A35]

CAT#: AM31356FC-N

Thrombomodulin (THBD) mouse monoclonal antibody, clone B-A35, FITC

Product Images

A typical staining pattern with the B-A35 monoclonal antibody of monocytes.

Specifications

Product Data

• Clone Name: B-A35
• Applications: FC
• Recommended Dilution: Flow Cytometry: Use 10 µl to label 10e6 cells or 100 µl of whole blood.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: TF1 cell line.
• Specificity: Recognises the soluble antigen.
  Recognises Thrombomodulin (TM), a 105 kDa protein.
• Formulation: PBS containing 5% BSA as stabilizer and 0.09% Sodium Azide as preservative
  Label: FITC
  State: Liquid purified IgG fraction
• Purification: Ion Exchange Chromatography
• Conjugation: FITC
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens thrombomodulin (THBD)
• Database Link:
  Entrez Gene 7056 Human
• Background: CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.
• Synonyms: Thrombomodulin, THRM, Fetomodulin

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Complement and coagulation cascades