Thrombomodulin (THBD) Mouse Monoclonal Antibody [Clone ID: B-A35]

CAT#: AM31360AF-N

Thrombomodulin (THBD) mouse monoclonal antibody, clone B-A35, Azide Free

Specifications

Product Data

• Clone Name: B-A35
• Applications: ELISA
• Recommended Dilution: ELISA Capture Antibody: This antibody can be used as Capture in a Human CD141 Sandwich Immunoassay to detect Human CD141 in combination with Biotinylated Human CD141 Detection Antibody AM31361BT-N.
  Suggested Coating Concentration: 0.2-1 µg/ml.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: TF1 cell line.
• Specificity: Recognises Thrombomodulin (TM), a 105 kDa protein.
• Formulation: PBS, Sterile-filtered through 0.22 µm, Carrier and preservative free
  State: Azide Free
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Ion Exchange Chromatography
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens thrombomodulin (THBD)
• Database Link:
  Entrez Gene 7056 Human
• Background: CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.
• Synonyms: Thrombomodulin, THRM, Fetomodulin

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Complement and coagulation cascades