CEACAM5 Mouse Monoclonal Antibody [Clone ID: B464M]
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Specifications
Product Data | |
Clone Name | B464M |
Applications | ELISA, IHC |
Recommended Dilution | ELISA. This Clone B464M can used as Capture antibody and B459M as Detection antibody. Immunohistochemistry. Staining in Immunohistochemistry: Brightness 80 Cytoplasmic staining 3+ Membrane staining 2+ Background 2+ Staining of mucus 2+ |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Human natural tumor-derived purified CEA antigen |
Specificity | CEA, epitope specificity group I. Does not crossreact with Human leukocytes in Cytofluorometry. |
Formulation | 10mM Tris, pH 7.5 containing 0.15M Sodium Chloride State: Purified State: Liquid purified IgG fraction (> 90% pure by SDS-PAGE) Preservative: 0.05% Sodium Azide |
Concentration | lot specific |
Purification | Ion Exchange Chromatography |
Storage | Store undiluted at 2-8°C. DO NOT FREEZE! |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens carcinoembryonic antigen related cell adhesion molecule 5 (CEACAM5), transcript variant 1 |
Database Link | |
Background | CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family (1). The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker (2). CEACAM6 expression is strongly up-regulated already during early stages of adenocarcinoma formation (3). The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria. |
Synonyms | CEA, Carcinoembryonic antigen |
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