PDE9A Mouse Monoclonal Antibody [Clone ID: 4E1]

CAT#: AM31702PU-N

PDE9A mouse monoclonal antibody, clone 4E1, Purified

Product Images

Detection limit for recombinant GST tagged PDE9A is 1 ng/ml as a capture antibody.

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  Human Adrenal Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Prostate, Epithelium: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 4E1
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant protein
• Specificity: This antibody reacts to PDE9A.
• Formulation: PBS, pH 7.2
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 0.5 mg/ml
• Purification: Affinity chromatography on Protein A
• Gene Name: Homo sapiens phosphodiesterase 9A (PDE9A), transcript variant 2
• Database Link:
  Entrez Gene 5152 Human
• Background: Phosphodiesterase 9A is a cGMP-specific phosphodiesterase. PDE9A activity is inhibited by zaprinast, but it is insensitive to rolipram, vinpocetine, SKF-94120, dipyridamole, and IBMX. More than 20 alternatively spliced variants have been reported (Rentero et al. 2003). PDE9A has been implicated in penile erectile dysfunction, as well as in functional disturbances in which intraneuronal signal transmission via second messengers are important in the pathophysiology (example, bipolar affective disorder). PDE9A is the only cGMP-specific PDE with significant expression in the forebrain, and as such is likely to function in NO-cGMP signaling.
• Synonyms: Phosphodiesterase 9A, Phosphodiesterase PDE9A21, HSPDE9A2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Progesterone-mediated oocyte maturation, Purine metabolism