Cyclin H (CCNH) Mouse Monoclonal Antibody [Clone ID: 1B8]

CAT#: AM31734PU-N

Cyclin H (CCNH) mouse monoclonal antibody, clone 1B8, Purified

Product Images

Western Blot analysis of CCNH expression in HeLa cell lysate.

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  Western Blot analysis of CCNH expression in transfected 293T cell line. Lane 1: CCNH transfected lysate (37.6 KDa). Lane 2: Non-transfected lysate.

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  Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Immunofluorescence of monoclonal antibody to CCNH on HeLa cell at 10 mg/ml.

Specifications

Product Data

• Clone Name: 1B8
• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA.
  Immunofluorescence: 10 µg/ml.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: CCNH antibody was raised against CCNH (AAH05280, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag.
• Specificity: Recognizes CCNH / Cyclin H.
• Formulation: PBS, pH 7.2
  State: Purified
  State: Liquid purified Ig fraction
• Purification: Protein A Chromatography
• Storage: Store the antibody (in aliquots) at -20°C or -80°C.
  Avoid freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens cyclin H (CCNH), transcript variant 1
• Database Link:
  Entrez Gene 902 Human
• Background: Cyclin H is a member of the cyclin-dependent protein kinase family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin H forms a trimeric complex with cyclin H and MAT1, which functions as a CDK-activating kinase (CAK). Cyclin H is an essential component of the transcription factor TFIIH that is involved in transcription initiation and DNA repair.
• Synonyms: Cyclin-H, MO15-associated protein, p37, p34, CCNH

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Cell cycle, Nucleotide excision repair