FOXO3 (361-460) Mouse Monoclonal Antibody [Clone ID: 2C5]

CAT#: AM31788PU-N

FOXO3 (361-460) mouse monoclonal antibody, clone 2C5, Purified

Product Images

Detection limit for recombinant GST tagged FOXO3A is approximately 0.3ng/ml as a capture antibody.

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  Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Immunofluorescence of monoclonal antibody to FOXO3 on HeLa cell. [antibody concentration 10 ug/ml]

Specifications

Product Data

• Clone Name: 2C5
• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA.
  Immunofluorescence: 10 µg/ml.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: FOXO3 antibody was raised against fOXO3A (AAH21224, 361 a.a. ~ 460 a.a) partial recombinant protein with GST tag.
• Specificity: This antibody reacts to FOXO3 / FOXO3A at aa 361-460.
• Formulation: PBS, pH 7.4
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Storage: Store the antibody (in aliquots) at -20°C to -80°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens forkhead box O3 (FOXO3), transcript variant 1
• Database Link:
  Entrez Gene 2309 Human
• Background: Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
• Synonyms: FOXO3A, AF6q21 protein

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Chemokine signaling pathway, Endometrial cancer, Neurotrophin signaling pathway, Non-small cell lung cancer