Filamin A (FLNA) Mouse Monoclonal Antibody [Clone ID: 4E10-1B2]

CAT#: AM31790PU-N

Filamin A (FLNA) mouse monoclonal antibody, clone 4E10-1B2, Purified

Product Images

Western Blot analysis of FLNA expression in HL-60 cell lysate.

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  Detection limit for recombinant GST tagged FLNA is approximately 0.03ng/ml as a capture antibody.

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  Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 4E10-1B2
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: FLNA antibody was raised against FLNA (AAH14654, 1 a.a. ~ 839 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Specificity: This antibody reacts to FLNA / FMD.
• Formulation: PBS, pH 7.2
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Storage: Upon receipt, store (in aliquots) at -20°C to -80°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens filamin A (FLNA), transcript variant 2
• Database Link:
  Entrez Gene 2316 Human
• Background: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking.
• Synonyms: Alpha-filamin, Filamin-1, Non-muscle filamin, FLNA, FLN, FLN1

Reference Data

• Protein Pathways: Focal adhesion, MAPK signaling pathway