MRP8 (S100A8) Mouse Monoclonal Antibody [Clone ID: CF-145]

CAT#: AM31838BT-N

MRP8 (S100A8) mouse monoclonal antibody, clone CF-145, Biotin

Specifications

Product Data

• Clone Name: CF-145
• Applications: FC, IF, IHC, WB
• Recommended Dilution: Flow Cytometry: 0.5 µg/1x10e6 cells.
  Immunofluorescence.
  Western blot.
  Immunohistochemistry.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Purified granulocyte antigen of Human origin.
• Specificity: This antibody detects Calgranulin A (S100A8).
• Formulation: PBS containing 0.02% Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml.
  Label: Biotin
  State: Liquid purified IgG fraction.
• Concentration: lot specific
• Purification: Protein G Chromatography of Ascitic fluid.
• Conjugation: Biotin
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens S100 calcium binding protein A8 (S100A8), transcript variant 4
• Database Link:
  Entrez Gene 6279 Human
• Background: Calgranulin A, also known as MRP-8 and S100A8 is a member of the S100 family of proteins containing 2 EF hand (alpha helix, turn, alpha helix structure) calcium binding motifs. S100 proteins are localized in the cytoplasm and /or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation.
  MRP-8 (S100A8) forms a heterodimeric complex with Calgranulin B, (MRP-14, S100A9) in the cytosol of monocyte and neutrophil cell types circulating in peripheral blood. Calgranulin A is found in elevated levels in the serum of cystic fibrosis cases and is also expressed in the skin of patients with psoriasis, eczematous dermatitis and squamous cell carcinoma.
• Synonyms: S100-A8, CAGA, MRP-8, CFAG