PF4 Mouse Monoclonal Antibody [Clone ID: RTO]

CAT#: AM31850PU-N

PF4 mouse monoclonal antibody, clone RTO, Purified


USD 475.00

2 Weeks*

Size
    • 200 ug

Product Images

Specifications

Product Data
Clone Name RTO
Applications ELISA, WB
Recommended Dilution ELISA: Use at 0.016 μg/ml.
Western blot.
Reactivities Human
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Human Factor IV purified from the supernatant of Thrombin activated platelets.
Specificity This antibody is specific for Human Platelet Factor IV.
AM31850PU-N (clone RTO) is seen to bind free PF4 in the absence of any bound Heparin. This is unlike AM31851PU-N (clone KKO), which binds PF4/heparin complexes to a similar degree as auto-antibodies found in individuals with Heparin-Induced Thrombocytopenia/Thrombosis (HIT/HITT).
Formulation PBS containing 0.02% Sodium Azide as preservative.
State: Purified
State: Liquid purified IgG fraction.
Concentration lot specific
Purification Protein G Chromatography of Ascitic fluid.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens platelet factor 4 (PF4)
Background Platelet Factor IV (PF4) is a 70 aa protein released from the alpha granules of activated platelets. PF4 is synthesized by bone marrow megakaryocytes and stored in alpha granules as a non-covalent bound tetramer. Platelet factor IV binds with high affinity to heparin and plays a role in inflammation and wound repair. PF4 is a chemoattractant for neutrophils, monocytes and fibroblasts and has been reported to be an immunologic regulator that inhibits suppressor T-cell activity.
Synonyms PF-4, Iroplact, Oncostatin-A, CXCL4, SCYB4
Reference Data
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Chemokine signaling pathway, Cytokine-cytokine receptor interaction

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.