BCL3 Hamster Monoclonal Antibody [Clone ID: Ham150-3.5]

CAT#: AM31856BT-L

BCL3 hamster monoclonal antibody, clone Ham150-3.5, Biotin

Specifications

Product Data

• Clone Name: Ham150-3.5
• Applications: ELISA
• Recommended Dilution: This Clone has been described to work in ELISA, Western Blot and Flow Cytometry.
• Reactivities: Human, Mouse
• Host: Hamster
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant Bcl-3-6-histidine tag from Armenian Hamster.
  Fusion Partner: SP2/0 myeloma.
• Specificity: Recognizes B-cell Leukemia/lymphoma 3
• Formulation: PBS containing 0.02% Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml.
  Label: Biotin
  State: Liquid purified IgG fraction.
• Concentration: 0.1 mg/ml
• Purification: Protein G Affinity Chromatography.
• Conjugation: Biotin
• Gene Name: Homo sapiens B-cell CLL/lymphoma 3 (BCL3)
• Database Link:
  Entrez Gene 602 Human
• Background: B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells.
  Bcl-3 has been shown to have versatile functions such as cytoplasmic activation of p50 homodimers, translocation to the nucleus, and modulation of the transcriptional machinery in the nucleus. Bcl-3 activity often relies on several nuclear interacting proteins such as Tip60, Jab1, Bard1, and Pirin. The Mouse Bcl-3 coding region exhibits 80% homology with Human Bcl-3 which is associated with human B-cell chronic lymphocytic leukemias (CLLs).
  Bcl-3 is detected in various tissues such as spleen and other lymphoid organs.
• Synonyms: BCL3, BCL4, D19S37

Reference Data

• Protein Families: Druggable Genome, Transcription Factors