TXNDC4 (ERP44) (30-407) Mouse Monoclonal Antibody [Clone ID: 3C7]

CAT#: AM31869PU-N

TXNDC4 (ERP44) (30-407) mouse monoclonal antibody, clone 3C7, Purified

Product Images

Western Blot analysis of TXNDC4 expression in A-431 using TXNDC4 antibody.

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  Western Blot analysis of TXNDC4 expression in K-562 using TXNDC4 antibody.

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  Detection limit for recombinant GST tagged TXNDC4 is 1 ng/ml as a capture antibody.

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  Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

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  Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

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Specifications

Product Data

• Clone Name: 3C7
• Applications: ELISA, IHC, IP, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 3 - 5 µg/ml.
  Immunoprecipitation.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: ERP44 antibody was raised against TXNDC4 (AAH05374, 30 a.a. ~ 407 a.a) full length recombinant protein with GST tag.
• Specificity: This antibody recognizes ERP44 / TXNDC4 at aa 30-407.
• Formulation: PBS, pH 7.2
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 0.44 mg/ml
• Purification: Protein A Chromatography
• Gene Name: Homo sapiens endoplasmic reticulum protein 44 (ERP44)
• Database Link:
  Entrez Gene 23071 Human
• Background: TXNDC4/ERp44/KIAA0573 was identified via its interaction with Erol-Lalpha, which in turn has been shown to regulate oxidative protein folding by selectively oxidizing protein disulfide isomerase. TXNDC4 is induced during ER stress and forms mixed disulfides with both hEROs and cargo folding intermediates. Over expression has been shown to alter the equilibrium of the different Ero1-Lalpha redox isoforms suggesting that TXNDC4 may be involved in the control of oxidative protein folding. It has also been suggested that TXNDC4 senses the environment in the ER lumen because it modulates IP3R1 (1,4,5-triphosphate receptor type 1) activity thereby regulating cytosolic calcium concentrations and intraluminal conditions.
• Synonyms: KIAA0573

Reference Data

• Protein Families: Druggable Genome