Pdcd1 Hamster Monoclonal Antibody [Clone ID: J43]

CAT#: AM31881PU-N

Pdcd1 hamster monoclonal antibody, clone J43, Purified


USD 330.00

2 Weeks*

Size
    • 250 ug

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Specifications

Product Data
Clone Name J43
Applications FC
Recommended Dilution Flow Cytometry.
Reactivities Mouse
Host Hamster
Isotype IgG
Clonality Monoclonal
Immunogen PD-1 cDNA transfectant.
Donor: mouse ascites fluid.
Fusion Partner: Mouse myeloma P3U1.
Specificity This Monoclonal Antibody reacts with Mouse PD-1 (Programmed Death-1).
Formulation PBS containing 0.02% Sodium Azide as preservative
State: Purified
State: Liquid purified IgG fraction
Concentration 1.0 mg/ml
Purification Protein G Chromatography
Gene Name Mus musculus programmed cell death 1 (Pdcd1)
Background CD279 is 50-55kD membrane protein which is a member of the CD28 family, and functions mainly as a negative regulator of T-cell activation. CD279 has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance. CD279 is inducibly expressed by T-cells, B-cells, NK-T-cells and monocytes upon activation. Loss of CD279 function has been associated with a number of autoimmune diseases, including rheumatoid arthritis, type I diabetes and ankylosing spondylitis. Recent studies suggest that CD279 could be targeted therapeutically in the treatment of HIV infection to reduce T-cell exhaustion.
Synonyms Protein PD-1, hPD-1, PDCD1
Note TEST RESULTS (Figure 1.)
Tissue Distribution by Flow Cytometry Analysis:
Mouse Strain: Balb/c
Antibody Concentration Used: 2.0 µg/10e6 cells.
Isotypic Control (shaded): Purified Hamster IgG.
Reference Data

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