Emilin1 Rat Monoclonal Antibody [Clone ID: C11A8]

CAT#: AM31889PU-N

Emilin1 rat monoclonal antibody, clone C11A8, Purified

Product Images

Cryostat sections of normal Mouse tissues stained with anti-Emilin-1 antibodies. In all Mouse tissues and organs examined, Emilin-1 was uniformly distributed in the stroma. In the skin, Emilin-1 staining colocalizes with LYVE-1-positive lymphatic vessels surrounding hair follicles. In the small intestine, it colocalizes with LYVE-1-positive lacteals and submucosal lymphatic vessels. At higher magnification, in the lung and lymph nodes, it is more evident that Emilin-1 is distributed at the abluminal surfaces of LECs. In the lymph node, Emilin-1-positive fibers connecting LECs to the surrounding ECM are evident.

Specifications

Product Data

• Clone Name: C11A8
• Applications: IF, IHC, WB
• Recommended Dilution: Western Blot: 2-10 µg/ml.
  Immunofluorescence.
  Immunohistochemistry on Frozen Sections.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Recombinant Mouse Emilin-1
• Specificity: This antibody was selected for its ability to detect Murine Emilin-1.
• Formulation: PBS
  State: Purified
  State: Lyophilized (0.2 μm filtered) purified IgG fraction
• Reconstitution Method: Restore in sterile water to a concentration is 0.1-1.0 mg/ml. Centrifuge vial prior to opening.
• Purification: Affinity Chromatography on Protein G
• Gene Name: Mus musculus elastin microfibril interfacer 1 (Emilin1)
• Database Link:
  Entrez Gene 100952 Mouse
• Background: Emilin-1 is an extracellular matrix glycoprotein localized at sites where elastin and microfibrils are in proximity. It may be responsible for anchoring smooth muscle cells to elastic fibers. It has cell adhesive capacity. Emilin-1 may have a role in the regulation of blood vessel assembly since it inhibits TGFB signaling by binding specifically to the pro-TGFB precursor and preventing its maturation by furin convertases in the extracellular space. TGFB proteins are the main regulators of blood vessel development and maintenance.
• Synonyms: EMILIN-1, EMI