MARCKS like protein (MARCKSL1) (107-196) Mouse Monoclonal Antibody [Clone ID: 8C8]

CAT#: AM31898PU-N

MARCKS like protein (MARCKSL1) (107-196) mouse monoclonal antibody, clone 8C8, Purified

Product Images

Western Blot analysis of MARCKSL1 expression in transfected 293T cell line by MARCKSL1 antibody.

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  Detection limit for recombinant GST tagged MARCKSL1 is approximately 0.1ng/ml as a capture antibody.

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  Human Tonsil, Germinal Center: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 8C8
• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1/500 - 1/1000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: MARCKSL1 (NP_075385, 107 a.a. ~ 196 a.a) partial recombinant protein with GST tag
• Specificity: Recognizes Marcks-Related Protein at aa 107-196.
• Formulation: PBS, pH 7.2
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: 0.22 mg/ml
• Purification: Protein A Chromatography
• Gene Name: Homo sapiens MARCKS like 1 (MARCKSL1), transcript variant 1
• Database Link:
  Entrez Gene 65108 Human
• Background: Protein kinase C is a key enzyme of intracellular signal transduction. The myristoylated, alanine-rich protein MARCKS, is a widely expressed, prominent substrate for protein kinase C.The severe neural tube defects (NTD) including exencephaly, spina bifida, and tail flexion anomaly in approximately 60% of the homozygous mutants and in approximately 10% of heterozygous animals. The homozygous mutants without exencephaly survived despite brain abnormalities, which appear to occur secondarily to the NTD.It has been suggested that mutations in Mrp result in isolated NTD and therefore may provide an animal model for common human NTD.
• Synonyms: MARCKS-related protein, Macrophage myristoylated alanine-rich C kinase substrate, MARCKSL1, MLP, MRP

Reference Data

• Protein Pathways: Fc gamma R-mediated phagocytosis