Complement C9 (C9) Mouse Monoclonal Antibody [Clone ID: 64E9]

CAT#: AM31909SU-N

Complement C9 (C9) mouse monoclonal antibody, clone 64E9, Liquid

Product Images

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Specifications

Product Data

• Clone Name: 64E9
• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 1/200.
  Western Blot: 1/2000.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Protein purified from Human plasma.
• Specificity: Recognizes Human Complement C9.
• Formulation: HEPES with 0.15M NaCl, 0.01% BSA, 0.03% Sdium Azide and 50% Glycerol
  State: Liquid
• Concentration: lot specific
• Purification: Ammonium Sulfate Precipitation
• Storage: Store the antibody undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens complement component 9 (C9)
• Database Link:
  Entrez Gene 735 Human
• Background: C9 is synthesised in the liver and monocytes, and is a plasma protein consisting of a single polypeptide chain of molecular weight 71kDa. Normal plasma concentration is 60mg/L. C9 forms part of the membrane attack complex (MAC) the cytolytic terminal complex of the complement pathways. C9 binds to the membrane associated C5b-8, binding of C9 to C5b-8 leads to the circular polymerisation of 12-18 C9 molecules. This is the basis of the hydrophilic, proteinwalled, trans-membrane channel formed by the MAC, which leads to cell lysis and destruction.
• Synonyms: Complement component C9, Complement 9

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Complement and coagulation cascades, Prion diseases, Systemic lupus erythematosus